The Renal Research Group at UiB and its main collaborative institutions
A multidisciplinary, clinically oriented renal research group
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The Renal Research Group听
The Renal Research Group belongs to the Department of Clinical Medicine at UiB with strong links to the Renal Unit at (Helse Bergen). The group is an open forum for clinical and translational kidney research in Bergen and has been directed by . Traditionally, the Renal Research Group has combined human/animal studies of disease mechanisms and molecular kidney biopsy analyses with epidemiological studies of risk factors of chronic kidney disease.
Senior Scientists听belong to the group, including Prof. Hans-Peter Marti.听听笔谤辞蹿. Einar Svarstad and Camilla T酶ndel, PhD, direct all clinical and histological Fabry studies together with Rannveig Skrunes, PhD.听Prof. Bj酶rn E. Vikse at UiB and (Haugesund Hospital), the winner of the 2017 of our Faculty of Medicine, has a particular focus on epidemiology and on proteomics (e.g. IgA nephropathy). Associate Prof. Sabine Leh, the renal pathologist of the Norwegian Kidney Biopsy Registry (NKBR), is instrumental in all studies related to kidney histology, including automated image analysis. Associate Professor Thomas Knoop and Professor Rune Bj酶rneklett have translational and clinical projects on IgA nephropathy and C3 nephropathy.
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The Core Group听
Within the Renal Research Group, we have a core group under the direction of Associate Professor听脴ystein Eikrem, MD, PhD, as the principal investigator (PI), and听Professor听Hans-Peter Marti
Postdoctoral fellows:听Lea Landolt, MD, PhD, Nazar Mohamed, BDS, MSc, PhD.
Researchers (former postdocs): Jessica Furriol, PhD, Tarig Osman, BDS PhD, and听Omnia Shadad, BDS PhD.
PhD students: Ole Petter Nordb酶, Tony Chen, Eleni Skandalou, Simen Femanger Pettersen and August Hoel.
Forskerlinje students: Even Koch, Mariell Rivedal, Marthe Alvestad, Sammy Choi and Sigrid Nakken. 听
Methodologies听
RRG members have extensive experience with the key methodology of all ongoing projects, including the proposed PhD theses. Examples are clinical epidemiology, statistics & bioinformatics, investigation of renal histology by stereology & automated image analyses, laser capture microdissection of nephron compartments of renal biopsies, next-generation sequencing of mRNA & miRNA, proteomics, CRISPR/Cas9 technology, cell culturing and interventional animal studies.
Laboratory infrastructure听
Respective laboratory space including animal facilities and all necessary apparatus is available in our institution at the University of Bergen. They are either located in the (e.g. Renal Laboratory on the 7th floor) or in the adjacent Building for Basic Biological Research (BBB) of the Department of Biomedicine.
Funding听
The studies of the core group are funded mainly through the support of Helse Vest, the Research Council of Norway and four competitive international industry grants (Sanofi-Genzyme, Takeda-Shire, Amicus and Alexion) to Hans-Peter Marti. More info
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Current Main Research Projects听
The core group of Hans-Peter Marti is involved in three main projects:
- Norwegian Study for Personalized and Data-based Management of Children and Adolescents with Chronic Kidney Disease (minimal change disease and focal segmental glomerulosclerosis). Research Council of Norway, 2023-2028
- Patient-tailored management of hypertensive nephropathy through digital technologies. Helse Vest, 2020-2024.
- Novel biomarkers and therapeutic targets in human and animal Fabry nephropathy as well as听in human membranous nephropathy, open and ongoing.
We would be very happy indeed to welcome students from all over Norway to join these projects!
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Key Collaborative Institutions听
We foster an interdisciplinary, well-funded research environment that involves a in academia and industry.
The Norwegian Kidney Biopsy Registry (NKBR) at Helse Bergen: 听NKBR provides Fabry nephropathy and membranous nephropathy samples.
Department of Clinical Science, at UiB:听Gunnar Houge for CRISPR/Cas9 studies, and Nicolas Delaleu, PhD, for bioinformatic analyses of RNA sequencing data.
Biomedicine at UiB:听, PhD, for CRISPR/Cas9 studies.
Helse Stavanger:听Terje Apeland, PhD, Nephrology, , for analyses of redox biomarkers.
NTNU and St. Olav University Hospital, Trondheim: 听 and for hypertensive nephropathy analyses.
University of Bristol, Bristol, UK: from pediatric nephrology for the NURTuRE biobank regarding MCD/FSGS biosamples.
Karolinska Institutet, Sweden:, , and from pediatric nephrology regarding MCD/FSGS biosamples.
University of Helsinki, Finland: for single-cell podocyte sequencing in archival kidney biopsies, and Andreas Scherer for bioinformatic analyses.
University of Oslo (UiO):听, PhD听and , PhD, from Rikshospitalet for Fabry and diabetic nephropathy studies.
University of Porto, Portugal: and his group for analyses of perioxidasin in chronic kidney disease.
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