大象传媒

H酶yland LE, VanLinden MR, Niere M, Str酶mland 脴, Sharma S, Dietze J, Tol氓s I, Lucena E, Bifulco E, Sverkeli LJ, Cimadamore-Werthein C, Ashrafi H, Haukanes KF, van der Hoeven B, D枚lle C, Davidsen C, Pettersen IKN, Tronstad KJ, Mj酶s SA, Hayat F, Makarov MV, Migaud ME, Heiland I, Ziegler M (2024):听Subcellular NAD⁺听pools are interconnected and buffered by mitochondrial NAD⁺. Nat. Metab. 6, doi:听.

Ferrario E,听Kallio JP,听Emdadi M,听Str酶mland 脴,听Rack JGM,听Ziegler M (2024):听Evolution of fungal tuberculosis necrotizing toxin (TNT) domain-containing enzymes reveals divergent adaptations to enhance NAD cleavage. Protein Sci. 33, doi: .

Ferrario E, Kallio JP, Str酶mland 脴, Ziegler M (2023): Novel calcium-binding motif stabilizes and increases the activity of听Aspergillus fumigatus听别肠迟辞-狈础顿补蝉别.听叠颈辞肠丑别尘颈蝉迟谤测听62, doi:听.

Houry D, Raasakka A, Ferrario E, Niere M, Bifulco E, Kursula P,听Ziegler M (2023): Identification of structural determinants of nicotinamide phosphoribosyl transferase (NAMPT) activity and substrate selectivity.听J. Struct. Biol. 215, doi: .

Sverkeli LJ,听Hayat F,听Migaud ME,听Ziegler M (2021): Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD.听Biomolecules听11: 1044,听诲辞颈:听.

Str酶mland 脴,听Kallio JP,听Pschibul A,听Skoge RH, Har冒ard贸ttir HM, Sverkeli LJ, Heinekamp T, Kniemeyer O, Migaud ME,听Makarov MV,听Gossmann TI, Brakhage AA, Ziegler M (2021): Discovery of fungal surface NADases predominantly present in pathogenic species. Nat. Commun. 12, doi:听.

Bockwoldt M, Houry D, Niere M, Gossmann TI, Reinartz I, Schug A, Ziegler M, Heiland I听(2019): Identification of evolutionary and kinetic drivers of NAD-dependent signaling.听Proc. Natl. Acad. Sci. U. S. A.听116, doi:听.

Buonvicino D,听Mazzola F,听Zamporlini F,听Resta F,听Ranieri G,听Camaioni E,听Muzzi M,听Zecchi R,听Pieraccini G,听D枚lle C,听Calamante M,听Bartolucci G,听Ziegler M,听Stecca B,听Raffaelli N,听Chiarugi A (2018):听Identification of the nicotinamide salvage pathway as a new toxification route for antimetabolites.听Cell. Chem. Biol. 25, doi: .

Skoge RH, Ziegler M (2016):听SIRT2 inactivation reveals a subset of hyperacetylated perinuclear microtubules inaccessible to HDAC6. J. Cell Sci. 129, doi: .

VanLinden MR, D枚lle C, Pettersen IK, Kulikova VA, Niere M, Agrimi G, Dyrstad SE, Palmieri F, Nikiforov AA, Tronstad KJ, Ziegler M (2015):听Subcellular distribution of NAD⁺听between cytosol and mitochondria determines the metabolic profile of human cells. J. Biol. Chem. 290, doi: .

Love NR, Pollak N, D枚lle C, Niere M, Chen Y, Oliveri P, Amaya E, Patel S, Ziegler M (2015): NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanisms. Proc. Natl. Acad. Sci. U. S. A. 112, doi: .

Rack JG, VanLinden MR, Lutter T, Aasland R, Ziegler M (2014): Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform. J. Mol. Biol. 426, doi: .

Stavrum AK, Heiland I, Schuster S, Puntervoll P, Ziegler M (2013): Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data. J. Biol. Chem. 288, doi: .

Niere M, Mashimo M, Agledal L, D枚lle C, Kasamatsu A, Kato J, Moss J, Ziegler M (2012):听ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose). J. Biol. Chem. 287,听诲辞颈: .

Nikiforov A, D枚lle C, Niere M, Ziegler M (2011): Pathways and subcellular compartmentation of NAD biosynthesis in human cells: From entry of extracellular precursors to mitochondrial NAD generation. J. Biol. Chem. 286, doi: .

D枚lle C, Niere M, Lohndal E, Ziegler M (2010): Visualization of subcellular NAD pools and intra-organellar protein localization by poly-ADP-ribose formation. Cell. Mol. Life Sci. 67, doi: .

Lau C, D枚lle C, Gossmann TI, Agledal L, Niere M, Ziegler M (2010): Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases. J. Biol. Chem. 285, doi: .

D枚lle C, Ziegler M (2009): Application of a coupled enzyme assay to characterize nicotinamide riboside kinases. Anal. Biochem. 385, doi: .

Niere M, Kernstock S, Koch-Nolte F, Ziegler M (2008). Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix. Mol. Cell. Biol. 28, doi: .

Pollak N, Niere M, Ziegler M (2007): NAD kinase levels control the NADPH concentration in human cells. J. Biol. Chem. 282,听诲辞颈:听.

Berger F, Lau C, Ziegler M (2007): Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1. Proc. Natl. Acad. Sci. U. S. A. 104, doi: .

Berger F, Lau C, Dahlmann M, Ziegler M (2005): Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms. J. Biol. Chem. 280, doi: .

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Migaud ME,听Ziegler M,听Baur JA (2024):听Regulation of and challenges in targeting听NAD⁺听metabolism.听Nat. Rev. Mol. Cell. Biol. 25, doi: .

Str酶mland 脴,听Diab J,听Ferrario E,听Sverkeli LJ,听Ziegler M (2021): The balance between NAD⁺听biosynthesis and consumption in ageing. Mech. Ageing. Dev. 199, doi: .

Str酶mland 脴, Niere M, Nikiforov AA, VanLinden MR, Heiland I,听Ziegler M (2019):听Keeping the balance in NAD metabolism.听Biochem. Soc. Trans.听47, doi:听. Review

Nikiforov A, Kulikova V, Ziegler M (2015): The human NAD metabolome: Functions, metabolism and compartmentalization.听Crit. Rev. Biochem. Mol. Biol.听50, doi: .

D枚lle C, Skoge RH, Vanlinden MR, Ziegler M (2013): NAD biosynthesis in humans - Enzymes, metabolites and therapeutic aspects.听Curr. Top. Med. Chem.听13,听诲辞颈: .

Koch-Nolte F, Ziegler M (2013): Physiology of ADP-ribosylation.听FEBS J.听280, doi: .

Sch眉ler H, Ziegler M (2013): Pharmacology of ADP-ribosylation.听FEBS J.听280, doi: .

D枚lle C, Rack JG, Ziegler M (2013): NAD and ADP-ribose metabolism in mitochondria.听FEBS J.听280, doi: .

Chiarugi A, D枚lle C, Felici R, Ziegler M (2012):听The NAD metabolome - A听key determinant of cancer cell biology.听Nat. Rev. Cancer听12, doi: .

Koch-Nolte F, Fischer S, Haag F, Ziegler M (2011): Compartmentation of NAD⁺-dependent signalling.听FEBS Lett.听585, doi:.

Agledal L, Niere M, Ziegler M (2010): The phosphate makes a difference: Cellular functions of NADP.听Redox Rep.听15, doi: .

Lau C, Niere M, Ziegler M (2009): The NMN/NaMN adenylyltransferase (NMNAT) protein family.听Front. Biosci.听14, doi: .

Koch-Nolte F, Haag F, Guse AH, Lund F, Ziegler M (2009): Emerging roles of NAD⁺听and its metabolites in cell signaling.听Sci. Signal.听2, doi: .

Pollak N, D枚lle C, Ziegler M听(2007): The power to reduce: pyridine nucleotides - small molecules with a multitude of functions. Biochem J. 402,听诲辞颈:听.

Billington RA, Bruzzone S, De Flora A, Genazzani AA, Koch-Nolte F, Ziegler M, Zocchi E听(2006): Emerging functions of extracellular pyridine nucleotides. Mol Med. 12, doi:听

Ziegler M听(2005): A vital link between energy and signal transduction. FEBS J. 272, doi:听.

Oei SL, Keil C, Ziegler M听(2005): Poly(ADP-ribosylation) and genomic stability. Biochem Cell Biol. 83, doi: .

Berger F, Ram铆rez-Hern谩ndez MH, Ziegler M听(2004): The new life of a centenarian: signalling functions of NAD(P). Trends Biochem Sci. 29, doi:听.

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