Publications
Main content
H酶yland LE, VanLinden MR, Niere M, Str酶mland 脴, Sharma S, Dietze J, Tol氓s I, Lucena E, Bifulco E, Sverkeli LJ, Cimadamore-Werthein C, Ashrafi H, Haukanes KF, van der Hoeven B, D枚lle C, Davidsen C, Pettersen IKN, Tronstad KJ, Mj酶s SA, Hayat F, Makarov MV, Migaud ME, Heiland I, Ziegler M (2024):听Subcellular NAD+听pools are interconnected and buffered by mitochondrial NAD+.听Nat. Metab.听6, doi:听.
Liang KX,听Chen A,听Kianian A,听Kristiansen CK,听Yangzom T,听Furriol J,听H酶yland LE,听Ziegler M,听Kr氓kenes T,听Tzoulis C,听Fang EF,听Sullivan GJ,听Bindoff LA (2024):听Activation of Neurotoxic Astrocytes Due to Mitochondrial Dysfunction Triggered by听POLG听Mutation. Int. J. Biol. Sci. 20,听doi: .
Ferrario E,听Kallio JP,听Emdadi M,听Str酶mland 脴,听Rack JGM,听Ziegler M (2024):听Evolution of fungal tuberculosis necrotizing toxin (TNT) domain-containing enzymes reveals divergent adaptations to enhance NAD cleavage.听Protein Sci.听33, doi:听.
Ferrario E, Kallio JP, Str酶mland 脴, Ziegler M (2023): Novel calcium-binding motif stabilizes and increases the activity of听Aspergillus fumigatus听ecto-NADase.听Biochemistry 62, doi:听.
Goyal S, Paspureddi A, Lu MJ, Chan HR, Lyons SN, Wilson CN, Niere M, Ziegler M, Cambronne XA (2023): Dynamics of SLC25A51 reveal preference for oxidized NAD+听and substrate led transport. EMBO Rep. 24, doi: .
Houry D, Raasakka A, Ferrario E, Niere M, Bifulco E, Kursula P,听Ziegler M (2023): Identification of structural determinants of nicotinamide phosphoribosyl transferase (NAMPT) activity and substrate selectivity.听J. Struct. Biol. 215, doi: .
Kropotov A, Kulikova V, Solovjeva L, Yakimov A, Nerinovski K, Svetlova M, Sudnitsyna J, Plusnina A, Antipova M, Khodorkovskiy M, Migaud ME, Gambaryan S, Ziegler M, Nikiforov A (2022): Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells. J. Biol. Chem. 298, doi: .
Sharma S, Hsieh YC, Dietze J, Bockwoldt M,听Str酶mland 脴,听Ziegler M, Heiland I (2022): Early evolutionary selection of NAD biosynthesis pathway in bacteria.听Metabolites 12, doi: .
Kristiansen CK, Chen A,听H酶yland LE,听Ziegler M, Sullivan GJ, Bindoff LA, Liang KX (2022): Comparing the mitochondrial signatures in ESCs and iPSCs and their neural derivations. Cell Cycle听21, doi: .
Str酶mland 脴,听Diab J,听Ferrario E,听Sverkeli LJ,听Ziegler M (2021): The balance between NAD+听biosynthesis and consumption in ageing. Mech. Ageing. Dev.听199, doi: .
Lauritzen KH,听Olsen MB,听Ahmed MS,听Yang K,听Rinholm JE,听Bergersen听LH,听Esbensen QY,听Sverkeli LJ,听Ziegler M,听Attramadal H,听Halvorsen B,听Aukrust P,听Yndestad A (2021):听Instability in NAD+听metabolism leads to impaired cardiac mitochondrial function and communication. Elife 10,听doi: .
L眉scher B,听Ahel I,听Altmeyer M,听Ashworth A,听Bai P,听Chang P,听Cohen M,听Corda D,听Dantzer F,听Daugherty MD,听Dawson TM,听Dawson VL,听Deindl S,听Fehr AR,听Feijs KLH,听Filippov DV,听Gagn茅 JP,听Grimaldi G,听Guettler S,听Hoch NC,听Hottiger MO,听Korn P,听Kraus WL,听Ladurner A,听Lehti枚 L,听Leung AKL,听Lord CJ,听Mangerich A,听Matic I,听Matthews J,听Moldovan GL,听Moss J,听Natoli G,听Nielsen ML,听Niepel M,听Nolte F,听Pascal J,听Paschal BM,听Paw艂owski K,听Poirier GG,听Smith S,听Timinszky G,听Wang ZQ,听Y茅lamos J,听Yu X,听Zaja R,听Ziegler M (2021):听ADP-ribosyltransferases, an update on function and nomenclature.听FEBS J., doi: .
Sverkeli LJ,听Hayat F,听Migaud ME,听Ziegler M (2021): Enzymatic and chemical syntheses of Vacor analogs of nicotinamide riboside, NMN and NAD.听Biomolecules听11,听doi:听.
Ziegler M,听Monn茅 M,听Nikiforov A,听Agrimi G, Heiland I,听Palmieri F (2021):听Welcome to the Family: Identification of the NAD+听transporter of animal mitochondria as member of the solute carrier family SLC25.听Biomolecules 11,听.
Str酶mland 脴,听Kallio JP,听Pschibul A,听Skoge RH, Har冒ard贸ttir HM, Sverkeli LJ, Heinekamp T, Kniemeyer O, Migaud ME,听Makarov MV,听Gossmann TI, Brakhage AA, Ziegler M (2021): Discovery of fungal surface NADases predominantly present in pathogenic species. Nat. Commun. 12, doi:听.
Kropotov A, Kulikova V, Nerinovski K, Yakimov A, Svetlova M, Solovjeva L, Sudnitsyna J, Migaud ME, Khodorkovskiy M, Ziegler M, Nikiforov A (2021): Equilibrative nucleoside transporters mediate the import of nicotinamide riboside and nicotinic acid riboside into human cells.听Int. J. Mol. Sci.听22, doi: .
Luongo TS, Eller JM, Lu M-J, Niere M, Raith F, Perry C, Bornstein MR, Oliphint P, Wang L, McReynolds MR, Migaud ME, Rabinowitz JD, Johnson FB, Johnsson K, Ziegler M, Cambronne XA, Baur JA听(2020): SLC25A51 is a mammalian mitochondrial NAD+ transporter.听Nature 588,听doi:听.
Liang KX, Kristiansen CK, Mostafavi S, Vatne GH, Zantingh GA, Kianian A,听Tzoulis C,听H酶yland LE,听Ziegler M,听Megias Perez R,听Furriol J,听Zhang Z, Balafkan N,听Hong Y, Siller R,听Sullivan GJ, Bindoff LA (2020): Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations.听EMBO. Mol. Med. 12,听doi:听.
Ziegler M, Nikiforov AA (2020): NAD on the rise again. Nat. Metab.听2, doi: .
Gilmour BC, Gudmundsrud R, Frank J, Hov A, Lautrup S, Aman Y, R酶sj酶 H, Brenner C, Ziegler M, Tysnes OB, Tzoulis C, Omland T, S酶raas A, Holm酶y T, Bergersen LH, Storm-Mathisen J, Nilsen H, Fang EF (2020): Targeting NAD+听in translational research to relieve diseases and conditions of metabolic stress and ageing.听Mech. Ageing Dev.听186,听doi: .
Kulikova V, Shabalin K, Nerinovski K, Yakimov A, Svetlova M, Solovjeva L, Kropotov A, Khodorkovskiy M, Migaud ME,听Ziegler M,听Nikiforov A (2019): Degradation of extracellular NAD+听intermediates in cultures of human HEK293 cells. Metabolites听9,听doi:.
Bockwoldt M, Houry D, Niere M, Gossmann TI, Reinartz I, Schug A, Ziegler M, Heiland I听(2019): Identification of evolutionary and kinetic drivers of NAD-dependent signaling.听Proc. Natl. Acad. Sci. U. S. A. 116, doi:听.
Lee YG, Reader BF, Herman D, Streicher A, Englert JA,听Ziegler M, Chung S, Karpurapu M, Park GY, Christman JW, Ballinger MN (2019):听Sirtuin 2 enhances allergic asthmatic inflammation. JCI Insight听4, doi: .
Str酶mland 脴, Niere M, Nikiforov AA, VanLinden MR, Heiland I,听Ziegler M (2019):听Keeping the balance in NAD metabolism. Biochem. Soc. Trans.听47, doi: . Review
Shabalin K, Nerinovski K, Yakimov A, Kulikova V, Svetlova M, Solovjeva L, Khodorkovskiy M, Gambaryan S, Cunningham R, Migaud ME,听Ziegler M, Nikiforov A (2018): NAD Metabolome Analysis in Human Cells Using 鹿H NMR Spectroscopy. Int. J. Mol. Sci. 19, doi:听.
Varland S,听Aksnes H,听Kryuchkov F,听Impens F,听Van Haver D,听Jonckheere V,听Ziegler M,听Gevaert K,听Van Damme P,听Arnesen T (2018):听N-terminal Acetylation Levels Are Maintained During Acetyl-CoA Deficiency in听Saccharomyces cerevisiae.听Mol. Cell. Proteomics听17,听doi:听.
Buonvicino D,听Mazzola F,听Zamporlini F,听Resta F,听Ranieri G,听Camaioni E,听Muzzi M,听Zecchi R,听Pieraccini G,听D枚lle C,听Calamante M,听Bartolucci G,听Ziegler M,听Stecca B,听Raffaelli N,听Chiarugi A (2018):听Identification of the nicotinamide salvage pathway as a new toxification route for antimetabolites.听Cell. Chem. Biol. 25, doi: .
VanLinden MR, Niere M, Nikiforov AA, Ziegler M, D枚lle C (2017):听Compartment-specific poly-ADP-ribose formation as a biosensor for subcellular听NAD听pools. Methods Mol. Biol. 1608, doi: .
Skoge RH, Ziegler M (2016):听SIRT2 inactivation reveals a subset of hyperacetylated perinuclear microtubules inaccessible to HDAC6. J. Cell Sci. 129, doi: .
VanLinden MR, D枚lle C, Pettersen IK, Kulikova VA, Niere M, Agrimi G, Dyrstad SE, Palmieri F, Nikiforov AA, Tronstad KJ, Ziegler M (2015):听Subcellular distribution of NAD+ between cytosol and mitochondria determines the metabolic profile of human cells. J. Biol. Chem. 290,听doi: .
Kulikova V, Shabalin K, Nerinovski K, D枚lle C, Niere M, Yakimov A, Redpath P, Khodorkovskiy M, Migaud ME, Ziegler M, Nikiforov A (2015): Generation, release, and uptake of the NAD precursor nicotinic acid riboside by human cells. J. Biol. Chem. 290, doi: .
Nikiforov A, Kulikova V, Ziegler M (2015): The human NAD metabolome: Functions, metabolism and compartmentalization. Crit. Rev. Biochem. Mol. Biol. 50, doi: . Review
Aksnes H, Van Damme P, Goris M, Starheim KK, Marie M, St酶ve SI, Hoel C, Kalvik TV, Hole K, Glomnes N, Furnes C, Ljostveit S, Ziegler M, Niere M, Gevaert K, Arnesen T (2015): An organellar n伪-acetyltransferase, naa60, acetylates cytosolic N-termini of transmembrane proteins and maintains Golgi integrity. Cell Rep. 10, doi: .
Love NR, Pollak N, D枚lle C, Niere M, Chen Y, Oliveri P, Amaya E, Patel S, Ziegler M (2015): NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanisms. Proc. Natl. Acad. Sci. U. S. A. 112, doi:听.
Rack JG, Lutter T, Kj忙reng Bjerga GE, Guder C, Ehrhardt C, V盲rv S, Ziegler M, Aasland R (2014): The PHD finger of p300 influences its ability to acetylate histone and non-histone targets. J. Mol. Biol. 426, doi: .
Gossmann TI, Ziegler M (2014): Sequence divergence and diversity suggests ongoing functional diversification of vertebrate NAD metabolism. DNA Repair (Amst.)听23, doi: .
Blacker TS, Mann ZF, Gale JE, Ziegler M, Bain AJ, Szabadkai G, Duchen MR (2014): Separating NADH and NADPH fluorescence in live cells and tissues using FLIM. Nat. Commun. 29, doi: .
Skoge RH, D枚lle C, Ziegler M (2014): Regulation of SIRT2-dependent 伪-tubulin deacetylation by cellular NAD levels. DNA Repair (Amst.)听23, doi: .
Love NR, Ziegler M, Chen Y, Amaya E (2014): Carbohydrate metabolism during vertebrate appendage regeneration: What is its role? How is it regulated?: A postulation that regenerating vertebrate appendages facilitate glycolytic and pentose phosphate pathways to fuel macromolecule biosynthesis. Bioessays 36, doi: .
Rack JG, VanLinden MR, Lutter T, Aasland R, Ziegler M (2014): Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform. J. Mol. Biol. 426,听doi: .
D枚lle C, Skoge RH, Vanlinden MR, Ziegler M (2013): NAD biosynthesis in humans - Enzymes, metabolites and therapeutic aspects. Curr. Top. Med. Chem.听13,听doi: . Review
Stavrum AK, Heiland I, Schuster S, Puntervoll P, Ziegler M (2013): Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data. J. Biol. Chem. 288,听doi: .
Koch-Nolte F, Ziegler M (2013): Physiology of ADP-ribosylation. FEBS J. 280, doi: . Review
Sch眉ler H, Ziegler M (2013): Pharmacology of ADP-ribosylation. FEBS J. 280, doi: . Review
D枚lle C, Rack JG, Ziegler M (2013): NAD and ADP-ribose metabolism in mitochondria. FEBS J. 280, doi: . Review
Chiarugi A, D枚lle C, Felici R, Ziegler M (2012):听The NAD metabolome - A听key determinant of cancer cell biology. Nat. Rev. Cancer听12, doi: . Review
Niere M, Mashimo M, Agledal L, D枚lle C, Kasamatsu A, Kato J, Moss J, Ziegler M (2012):听ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose). J. Biol. Chem. 287, doi: .
Gossmann TI, Ziegler M, Puntervoll P, de Figueiredo LF, Schuster S, Heiland I (2012):听NAD(+) biosynthesis and salvage - A听phylogenetic perspective. FEBS J. 279, doi:
de Figueiredo LF, Gossmann TI, Ziegler M, Schuster S (2011): Pathway analysis of NAD+ metabolism. Biochem J. 439, doi:听.
Hottiger MO, Boothby M, Koch-Nolte F, L眉scher B, Martin NM, Plummer R, Wang ZQ, Ziegler M (2011): Progress in the function and regulation of ADP-Ribosylation. Sci. Signal. 4, doi: . Meeting report
Nikiforov A, D枚lle C, Niere M, Ziegler M (2011): Pathways and subcellular compartmentation of NAD biosynthesis in human cells: From entry of extracellular precursors to mitochondrial NAD generation. J. Biol. Chem. 286, doi: .
Koch-Nolte F, Fischer S, Haag F, Ziegler M (2011): Compartmentation of NAD+-dependent signalling. FEBS Lett. 585, doi:听. Review
Lau C, D枚lle C, Gossmann TI, Agledal L, Niere M, Ziegler M (2010): Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases. J. Biol. Chem. 285, doi: .
Agledal L, Niere M, Ziegler M (2010): The phosphate makes a difference: Cellular functions of NADP. Redox Rep. 15, doi:听. Review
D枚lle C, Niere M, Lohndal E, Ziegler M (2010): Visualization of subcellular NAD pools and intra-organellar protein localization by poly-ADP-ribose formation. Cell. Mol. Life Sci. 67, doi: .
Evjenth R, Hole K, Karlsen OA, Ziegler M, Arnesen T, Lillehaug JR (2009): Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity. J. Biol. Chem. 284, doi: .
Evjenth R, Hole K, Ziegler M, Lillehaug JR (2009): Application of reverse-phase HPLC to quantify oligopeptide acetylation eliminates interference from unspecific acetyl CoA hydrolysis. BMC Proc. 3 Suppl. 6, doi: .
Lau C, Niere M, Ziegler M (2009): The NMN/NaMN adenylyltransferase (NMNAT) protein family. Front. Biosci. 14, doi: . Review
Kellmann R, Schaffner CA, Gr酶nset TA, Satake M, Ziegler M, Fladmark KE (2009): Proteomic response of human neuroblastoma cells to azaspiracid-1. J. Proteomics听72, doi: .
Martino F, Kueng S, Robinson P, Tsai-Pflugfelder M, van Leeuwen F, Ziegler M, Cubizolles F, Cockell MM, Rhodes D, Gasser SM (2009): Reconstitution of yeast silent chromatin: Multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro. Mol. Cell. 33, doi: .
Koch-Nolte F, Haag F, Guse AH, Lund F, Ziegler M (2009): Emerging roles of NAD+ and its metabolites in cell signaling. Sci. Signal. 2, doi:听. Review
D枚lle C, Ziegler M (2009): Application of a coupled enzyme assay to characterize nicotinamide riboside kinases. Anal. Biochem. 385,听doi:听.
Niere M, Kernstock S, Koch-Nolte F, Ziegler M (2008):听Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix. Mol Cell Biol. 28, doi: .
Lewis AM, Masgrau R, Vasudevan SR, Yamasaki M, O'Neill JS, Garnham C, James K, Macdonald A, Ziegler M, Galione A, Churchill GC (2007): Refinement of a radioreceptor binding assay for nicotinic acid adenine dinucleotide phosphate. Anal. Biochem. 371,听doi:听.
Pollak N, Niere M, Ziegler M (2007): NAD kinase levels control the NADPH concentration in human cells. J. Biol. Chem. 282, doi:听.
Billington RA, Bruzzone S, De Flora A, Genazzani AA, Koch-Nolte F, Ziegler M, Zocchi E (2006): Emerging functions of extracellular pyridine nucleotides. Mol. Med. 12, doi: . Review
Berger F, Lau C, Ziegler M (2007): Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1. Proc. Natl. Acad. Sci. U. S. A. 104, doi: .
Pollak N, D枚lle C, Ziegler M (2007): The power to reduce: Pyridine nucleotides - Small molecules with a multitude of functions. Biochem. J. 402, doi: .听Review
Churamani D, Dickinson GD, Ziegler M, Patel S (2006): Time sensing by NAADP receptors. Biochem J. 397, doi: .
Ziegler M (2005): A vital link between energy and signal transduction. FEBS J. 272, doi: . Review
Berger F, Lau C, Dahlmann M, Ziegler M (2005): Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms. J. Biol. Chem. 280, doi: .
Oei SL, Keil C, Ziegler M (2005): Poly(ADP-ribosylation) and genomic stability. Biochem. Cell. Biol. 83, doi: . Review
Ziegler M, Niere M (2004): NAD+ surfaces again. Biochem. J. 382, doi:听. Commentary
Berger F, Ram铆rez-Hern谩ndez MH, Ziegler M (2004): The new life of a centenarian: Signalling functions of NAD(P). Trends Biochem. Sci. 29,听doi: .听Review
Petermann E, Ziegler M, Oei SL (2003): ATP-dependent selection between single nucleotide and long patch base excision repair. DNA Repair (Amst.)听2, doi:听.
Werner E, Ziegler M, Lerner F, Schweiger M, Heinemann U (2002):听Crystal structure of human nicotinamide mononucleotide adenylyltransferase in complex with NMN. FEBS Lett. 516, doi:听.
Werner E, Ziegler M, Lerner F, Schweiger M, Muller YA, Heinemann U (2002): Crystallization and preliminary X-ray analysis of human nicotinamide mononucleotide adenylyltransferase (NMNAT). Acta Crystallogr. D Biol. Crystallogr. 58,听doi:.
Herrero-Yraola A, Bakhit SM, Franke P, Weise C, Schweiger M, Jorcke D, Ziegler M (2001): Regulation of glutamate dehydrogenase by reversible ADP-ribosylation in mitochondria. EMBO J. 20, doi: .
Lerner F, Niere M, Ludwig A, Ziegler M (2001): Structural and functional characterization of human NAD kinase. Biochem. Biophys. Res. Commun. 288, doi: .
Ziegler M, Oei SL (2001): A cellular survival switch: poly(ADP-ribosyl)ation stimulates DNA repair and silences transcription. Bioessays 23, doi: . Review.
Schweiger M, Hennig K, Lerner F, Niere M, Hirsch-Kauffmann M, Specht T, Weise C, Oei SL, Ziegler M (2001). Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis. FEBS Lett. 492, doi:听.
Oei SL, Ziegler M (2000). ATP for the DNA ligation step in base excision repair is generated from poly(ADP-ribose). J. Biol. Chem. 275, doi: .
Mayer-Kuckuk P, Ullrich O, Ziegler M, Grune T, Schweiger M (1999): Functional interaction of poly(ADP-ribose) with the 20S proteasome in vitro. Biochem. Biophys. Res. Commun. 259, doi: .
Jorcke D, Ziegler M, Herrero-Yraola A, Schweiger M (1998): Enzymic, cysteine-specific ADP-ribosylation in bovine liver mitochondria. Biochem. J. 332, doi:.
Oei SL, Griesenbeck J, Schweiger M, Ziegler M (1998). Regulation of RNA polymerase II-dependent transcription by poly(ADP-ribosyl)ation of transcription factors. J. Biol. Chem. 273, doi: .
Ziegler M, Jorcke D, Schweiger M (1997): Identification of bovine liver mitochondrial NAD+ glycohydrolase as ADP-ribosyl cyclase. Biochem J. 326, doi: 1.
Ziegler M, Jorcke D, Schweiger M (1997): Metabolism of cyclic ADP-ribose: a new role for NAD+ glycohydrolases. Rev. Physiol. Biochem. Pharmacol. 131, doi: . Review.
Griesenbeck J, Oei SL, Mayer-Kuckuk P, Ziegler M, Buchlow G, Schweiger M (1997): Protein-protein interaction of the human poly(ADP-ribosyl)transferase depends on the functional state of the enzyme. Biochemistry 36, doi: .
Oei SL, Griesenbeck J, Buchlow G, Jorcke D, Mayer-Kuckuk P, Wons T, Ziegler M (1996). NAD+ analogs substituted in the purine base as substrates for poly(ADP-ribosyl) transferase. FEBS Lett. 397, doi: .
Ziegler M, Jorcke D, Zhang J, Schneider R, Klocker H, Auer B, Schweiger M (1996). Characterization of detergent-solubilized beef liver mitochondrial NAD+ glycohydrolase and its truncated hydrosoluble form. Biochemistry 35, doi: .
