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A long term project has been on the in vivo聽interaction between collagen binding聽integrins, in particular 伪11尾1 and the聽伪V尾3 which is a non-collagen binding聽integrin, and which seems to take聽over the role of the collagen binding聽尾1-integrins. These studies聽demonstrate that both the matrix and聽the specific cell lines will affect tumor聽properties.聽
A particular feature of the group is the use of hyperbaric oxygen on experimental tumors as well as treatment modality for injury after irradiation injury.
We have demonstrated that hyperbaric oxygen聽treatment (HBOT) attenuates tumor聽growth in聽different breast cancer models (DMBA-induced mammary tumors, MDA-MB-231, BT-474, 4T1) and shifts the phenotype from聽mesenchymal to epithelial (MET). Notably, HBOT聽also reduced the number and area of metastatic聽lesions in the triple negative model MDA-MB-231.
We have also studied if different factors (hypoxia, Transforming Growth聽Factor -尾1 or Jagged-1) can induce epithelial-to mesenchymal transition (EMT) in four聽breast cancer cell lines with different hormone status. The conclusion was that single factors can induce mesenchymal-like morphology, but not promote full EMT.