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Paraneoplastic Neurological Syndromes (PNS) associated with this antibody:
- Cerebellar ataxia
Most frequently associated tumors:
- Breast cancer
- Ovarian cancer
- Uterus cancer
The onconeuronal听Yo antibody binds to two different proteins; cerebellar degeneration-related protein 2 (CDR2) and 2-Like (CDR2L). These proteins are quite similar and听have around听50 % sequence homology. Quite little is known about their location, interaction partners, regulation听and function in听neuronal cells. In the cerebellum the proteins are expressed in Purkinje neurons and cells of the moleculare layer (probably stellate and/or basket cells),听but they are听also expressed听in neuronal听cells听in the midbrain ().
听
Yo antibody staining in cerebellum.
Photo:
Mette Haugen
17.10.2016