Image Mass Cytometry (Hyprion) identification of kidney cancer biomarkers
Pilot Study: Hyperion Imaging System is a reliable tool for simultaneous detection of multiple markers in archival kidney biopsies.
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The HyperionTM Imaging System is a high-parameter imaging system that enables the simultaneous detection of
up to 40 protein markers using metal-tagged antibodies. It allows measurements of antigen
abundances at sub-cellular resolution and exploration of cell-cell interactions and can potentially
increase the diagnostic and pathophysiological yield of archival biopsies.
This project aimed to investigate this technique's applicability on archival formalin-fixed paraffin-embedded (FFPE) kidney biopsies.
Based on our first pilot study, further processing and data analysis would be needed to enable the exploration of the cell-cell interactions.