Preprint
Pushing structure-based design for new antibiotics
An Experimental Toolbox for Structure-Based Hit Discovery for P. Aeruginosa FabF, a Promising Target for Antibiotics
Photo:
Ludvik O. Espeland
Main content
Published: 03.05.2021
Our recent preprint has just been published on . The article is about FabF, which is an attractive target for new antibiotics. We describe an experimental toolbox to support structure-based drug design efforts for FabF from P. aeruginosa. The toolbox contains two types of binding assays (bio-layer interferometry and NMR assays) and robust conditions for soaking FabF crystals. We demonstrate that this toolbox is fit-for-purpose by validating hits obtained from virtual screening.
听