Image guided cytoreduction of ovarian cancer
CCBIO Postdoc Katrin Kleinmanns, together with CCBIO PhD Katharina Bischoff and Researcher Vibeke Fosse, recently published 2 articles in EBioMedicine. Their work describing CD24-targeted near-infrared (NIR) fluorescence imaging in patient-derived xenograft (PDX) models of high-grade serous ovarian carcinoma (HGSOC), confirms an improvement of cytoreduction of ovarian cancer in PDX orthotopic surgical model with CD24-targeted NIR FIGS. The journal also features the 2 publications in their commentary.
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PhD projects
The project, financed by The MSCA-ITN programme (ispic.eu), CCBIO and innovation grants from Helse Vest RHF and Helse Bergen HF, has been part of the PhD works of Katrin Kleinmanns and 碍补迟丑补谤颈苍补听叠颈蝉肠丑辞蹿.
鈥淭he cell surface antigen CD24, currently postulated in theranostic settings, meets the requirements of a specific imaging biomarker and therefore suggests to be an ideal target for our imaging approach,鈥� Katrin says. 鈥淲e want to develop our antibody-based fluorescence probe further into smaller targeting-moieties, as antibody fragments e.g. nanobodies, to meet enhanced pharmacokinetic characteristics. This can be tested in our palette of heterogenous orthotopic PDX聽models鈥�, she remarks.
Improving survival
聽鈥淭he results are very encouraging,鈥� said Medical director in Gynacological Oncology and CCBIO PI, Professor Line Bj酶rge. 鈥淭he fluorochrome-marked probes for tumour tissue detection can be used聽intraoperatively in the treatment of most types of solid malignant聽tumors, and thus may be very useful tools to improve the degree of survival in patients with advanced cancer,鈥� she concludes.
鈥淭he next step is to trial this technique in dogs with naturally occurring cancer, an ethically appealing model for many common human聽cancers鈥� states Fosse - veterinarian with specialisation in surgical聽oncology.
The 2 articles and commentary (A 鈥渓ight鈥� guide for surgery) appear in the May edition of the journal, with CCBIO PI Emmet McCormack as senior author.
The publications:
Kleinmanns K, Bischof K, Anandan S, Popa M, Akslen LA, Fosse V, Karlsen I, Gjertsen BT, Bj酶rge L, McCormack E. . EBioMedicine 2020.
Kleinmanns K, Fosse V, Davidson B, de Jal贸n EG, Tenstad O, Bj酶rge L, McCormack E. . EBio-Medicine 2020.
The commentary: Sato K. . EBioMedicine聽2020 Jun 4;56:102808.
