大象传媒

The objectives of the project are to a) identify transcriptional correlates of risk that predict the progression from infection to active TB in Indian cohorts; b) identify transcriptional correlates of infection protection that predict protection from infection or the establishment of latent TB infection; c) identify host biomarkers that predict treatment outcome in adult TB patients: d) assess and validate host transcriptional biosignatures of diagnostic utility for paediatric TB in a prospective cohort study and d) strengthen capacity relevant to TB-biomarker research at the appropriate participating institutions听

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Recent publications:

• Sivakumaran D, Jenum S, Ritz C, Vaz M, Doherty TM,听Grewal HMS.Front Immunol. 2022 Mar 17;13:801616. doi: 10.3389/fimmu.2022.801616.

• Sivakumaran D, Blatner G, Bakken R, Hokey D, Ritz C, Jenum S,听Grewal HMS.Front Immunol. 2021 Jun 11;12:673532. doi: 10.3389/fimmu.2021.673532

• Sivakumaran D, Jenum S, Vaz M, Selvam S, Ottenhoff THM, Haks MC, Malherbe ST, Doherty TM, Ritz C,听Grewal HMS.Commun Biol. 2020 Jul 9;3(1):359. doi: 10.1038/s42003-020-1087-x

• Sivakumaran D, Ritz C, Gj酶en JE, Vaz M, Selvam S, Ottenhoff THM, Doherty TM, Jenum S,听Grewal HMS.Front Immunol. 2021 Feb 4;11:626049. doi: 10.3389/fimmu.2020.626049

• Bekken GK, Ritz C, Selvam S, Jesuraj N, Hesseling AC, Doherty TM,听Grewal HMS, Vaz M, Jenum S.BMC Infect Dis. 2020 Jan 31;20(1):96. doi: 10.1186/s12879-020-4800-y

• Ronge L, Sloot R, Du Preez K, Kay AW, Kirchner HL,听Grewal HMS, Mandalakas AM, Hesseling AC.Pediatr Infect Dis J. 2021 Aug 1;40(8):763-770. doi: 10.1097/INF.0000000000003196.PMID:听

• Jeremiah K, Lyimo E, Ritz C, PrayGod G, Rutkowski KT, Korsholm KS, Ruhwald M, Tait D,听Grewal HMS, Faurholt-Jepsen D.PLoS One. 2021 Jun 7;16(6):e0252808. doi: 10.1371/journal.pone.0252808. eCollection 2021.PMID:听

• Jenum S, Selvam S, Jesuraj N, Ritz C, Hesseling AC, Cardenas V, Lau E, Doherty TM,听Grewal HMS, Vaz M.BMJ Open Respir Res. 2018 Oct 9;5(1):e000304. doi: 10.1136/bmjresp-2018-000304. eCollection 2018.

• Sivakumaran D, Jenum S, Srivastava A, Steen VM, Vaz M, Doherty TM, Ritz C,听Grewal HMS.Front Immunol. 2023 Jan 11;13:1051963. doi: 10.3389/fimmu.2022.1051963

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