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TargetRNA

DC 4: Hit discovery and structural studies of riboswitch-ligand complexes using NMR and X-ray crystallography

Research field: Structural biology, NMR spectroscopy, X-Ray crystallography.

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PhD project description:

This PhD project will focus on using NMR spectroscopy for the characterization of the structure and dynamics of two riboswitches in complex with small molecule ligands. Further, different biophysical screening modalities will be compared for the identification of fragment hits for RNA targets. The PhD student will work in an interdisciplinary environment where NMR spectroscopy is used to address structural, dynamic, and metabolomic data from different sources such as chemical, biochemical, or other natural systems. You will have opportunities to work with other scientists within and outside the TargetRNA 听doctoral network and to collaborate with and supervise undergraduate students.

Research environment:

The laboratory of Assoc. Prof. Charlotte H. Gotfredsen focuses on NMR spectroscopy for multiple uses in chemical biology and biological chemistry. The group carries out projects where NMR spectroscopy is used as the main analytical technique within RNA structure determination, secondary metabolite structure determination and in situ metabolomic studies as well as NMR based FBDD screening. Furthermore, we work with new developments within NMR spectroscopy both software for metabolomic data deconvolution and alignment media enabling the extraction of long-range NMR structural parameters.
You can read more about DTU Chemistry at and more about the CHG group and the NMR Center DTU at

Application to the position:

Application deadline听2 April 2025 (23:59 Danish time).

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Supervisor: Prof. Charlotte H. Gotfredsen.

Host institute: Department of Chemistry, Technical University of Denmark, Denmark.

Secondments planned: Malvern, United Kingdom, 2 months: fragment-screening using GCI; CrystalFirst (Industry, DE), 4 months: crystallographic fragment screening.

Doctoral program:听Chemistry at the Technical University of Denmark ()

Technical University of Denmark
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation, and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility. DTU Chemistry is a recognised department of chemistry within, physical chemistry, inorganic chemistry, and organic chemistry. The Department is responsible for research-based teaching at the BSc, MSc, as well as PhD levels. We encourage international collaboration both between scientists and the different scientific disciplines. The department currently has 150 employees including 25 faculty and 70 PhD students. The department has an extensive infrastructure of analytical equipment and hosts several centers including DTU Screening Core, DK-OPENSCREEN, and the NMR Center 鈥� DTU.
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Technical University of Denmark
12.03.2025