AE Lewis group
Lipid Function in the Nucleus听in Health and Diseases
Lipids听are essential for life. They are structural components of all cellular membranes but also function as energy stores, cellular signalling molecules, hormones and regulators of transcription factors. Recent lipidomics analyses in mammalian cells have highlighted the dynamic remodelling of different lipid species in health and diseases.
Our group studies the nuclear roles of the听signaling lipids, phosphoinositides, using quantitative interactomics, as well as biochemical, molecular and cell biology approaches in health and cancer biology.
Lipids in the nucleus: what are they doing there?
The signaling lipids听phosphoinositides (PPIn)听are found within the confine of the nucleus but their roles remain unclear. To fill this gap, our lab听has mapped听protein-PPIn interactomes听formed in this organelle (PMID:听 &听) and aim to identify altered networks in pathologic states for which the PPIn听metabolic pathways are known to be altered, particularly in cancer.
Our group is therefore interested in addressing the following questions:
1.听What are the functions of these interactions?
3.听Which protein-PPIn interactions are functionally disrupted in cancer and contribute its development?
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To learn more about nuclear PPIn and their interactomes,听check our reviewson听"" and听.
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Group Members
Aur茅lia E LEWIS - Group leader, research profile in , and听UiB.
Diana C. Turcu - lab manager
Bachelor-master students
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Location:听
H酶yteknologisenteret i Bergen, Bioblokken, 5th floor,
Thorm酶lensgate 55, 5008 Bergen,听
